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Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum |
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| Authors: | Jie Liu Kuniyoshi Shimizu Fumiko Konishi Kiyoshi Noda Shoichiro Kumamoto Kenji Kurashiki Ryuichiro Kondo |
| Affiliation: | aDepartment of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan;bChlorella Industries Co. Ltd., Research Laboratories, Fukuoka 833-0056, Japan;cKurume Research Park Co. Ltd., Fukuoka 839-0864, Japan |
| Abstract: | The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia. |
| Keywords: | 5α -Reductase Ganoderma lucidum Anti-androgen activities Benign prostatic hyperplasia Triterpenoid |
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