羟基乙酸的合成研究

以氯乙酸为原料合成了羟基乙酸 ,研究了多种反应条件下反应过程 ,尤其对反应温度和氢氧化钠质量分数等条件进行了筛选 ,有效控制了聚合反应的进行 ,同时使得氯乙酸原料中的杂质二氯乙酸反应成羟基乙酸 ,经过提纯分离使最终羟基乙酸的收率达 95 % ,产品质量分数达 98%以上

The Study of Synthesis of Hydroxyacetic Acid

Hydroxyacetic acid was synthesized by the hydrolysis of chloroacetic acid in the presence of aqueous NaOH.The effect of reaction temperature and concentration of sodium hydroxide on the reaction was investigated.Under the optimum condition,side reactions,such as the condensation of acids and formation of impurities,e.g.dichloroacetic acid,could be inhibited,the yield of hydroxyacetic acid reached above 95%.The procedure is as follows:the raw product from hydrolysis was acidified;the formed NaCl was removed by filtration;the filter liquid was mixed with acetone;the formed acetone solution containing hydroxyacetic acid was distilled;acetone was separated out.The product with purity of more than 98% was obtained through the vacuum distillation of the remainder.