| 4-甲基-2,3,5,6-四氟苯甲醇的合成 |
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| 引用本文： | 何明阳,陈圣春,谢英梅,陈群.4-甲基-2,3,5,6-四氟苯甲醇的合成[J].化工进展,2006,25(7):811-814. |
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| 作者姓名： | 何明阳 陈圣春 谢英梅 陈群 |
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| 作者单位： | 江苏工业学院,江苏省精细石油化工重点实验室,常州,213016;江苏工业学院,江苏省精细石油化工重点实验室,常州,213016;江苏工业学院,江苏省精细石油化工重点实验室,常州,213016;江苏工业学院,江苏省精细石油化工重点实验室,常州,213016 |
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| 摘 要： | 以2,3,5,6–四氟对苯二甲醇为起始原料，经氯化、常压催化氢解制得4–甲基–2,3,5,6–四氟苯甲醇。研究表明，在甲苯中用盐酸氯化时，温度为100～105℃、反应6 h、盐酸与2,3,5,6–四氟对苯二甲醇用量物质的量比为1.4，4–甲基–2,3,5,6–四氟苯甲醇产率为96.4%；在甲醇溶剂中以Pd/C为催化剂，温度为50℃、4–氯甲基–2,3,5,6–四氟苯甲醇与10%Pd/C与甲醇质量比为1∶0.05∶9.0，常压氢解4 h，4–甲基–2,3,5,6–四氟苯甲醇产率为99%，两步反应总产率为95.4%。
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| 关 键 词： | 四氟对苯二甲醇 氯化 氢解 4-甲基-2 3 5 6-四氟苯甲醇 |
| 文章编号： | 1000-6613（2006）07-0811-04 |
| 收稿时间： | 2006-03-30 |
| 修稿时间： | 2006-05-01 |
Synthesis of 4-methyl-2,3,5,6-tetrafluorobenzene methanol |
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| HE Mingyang,CHEN Shengchun,XIE Yingmei,CHEN Qun.Synthesis of 4-methyl-2,3,5,6-tetrafluorobenzene methanol[J].Chemical Industry and Engineering Progress,2006,25(7):811-814. |
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| Authors: | HE Mingyang CHEN Shengchun XIE Yingmei CHEN Qun |
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| Affiliation: | Jiangsu Provincial Key Lab. of Fine Petrochemical, Jiangsu Polytechnic University |
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| Abstract: | 4-Methyl-2,3,5,6-tetrafluorobenzenemethanol (Ⅲ) was prepared from 2,3,5,6–tetrafluoro–1,4–benzenedimethanol (Ⅰ) by chlorination and hydrogenolysis. In toluene, hydrochloric acid and (Ⅰ) in molar ratio 1.4 reacted at 100～105℃ for 6 h to yield 96.4% of 4–chloromethyl–2,3,5,6–tetrafluorobenzenemethanol (Ⅱ). In methanol, the catalytic hydrogenolysis of (Ⅱ) was carried out at 55℃ for 4 h with the mass ratio of (Ⅱ) to Pd/C catalyst to methanol= 1:0.05:9.0, with the (III) yield of 99%. The overall yield of the two -step synthesis was 95.4%. |
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