The Crucial Roles of Bmi-1 in Cancer: Implications in Pathogenesis,Metastasis, Drug Resistance,and Targeted Therapies |
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| Authors: | Jie Xu Lin Li Pengfei Shi Hongjuan Cui Liqun Yang |
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| Affiliation: | 1.State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China; (J.X.); (L.L.); (P.S.);2.Cancer Center, Medical Research Institute, Southwest University, Chongqing 400716, China |
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| Abstract: | B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved in regulating cell proliferation, differentiation and senescence, and maintaining the self-renewal of stem cells. Many studies in recent years have emphasized the role of Bmi-1 in the occurrence and development of tumors. In fact, Bmi-1 has multiple functions in cancer biology and is closely related to many classical molecules, including Akt, c-MYC, Pten, etc. This review summarizes the regulatory mechanisms of Bmi-1 in multiple pathways, and the interaction of Bmi-1 with noncoding RNAs. In particular, we focus on the pathological processes of Bmi-1 in cancer, and explore the clinical relevance of Bmi-1 in cancer biomarkers and prognosis, as well as its implications for chemoresistance and radioresistance. In conclusion, we summarize the role of Bmi-1 in tumor progression, reveal the pathophysiological process and molecular mechanism of Bmi-1 in tumors, and provide useful information for tumor diagnosis, treatment, and prognosis. |
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| Keywords: | Bmi-1 miRNAs tumorigenesis chemoresistance cancer therapy molecular mechanism |
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