FGFR3-TACCs3 Fusions and Their Clinical Relevance in Human Glioblastoma |
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Authors: | Hanna Gö tt,Eberhard Uhl |
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Affiliation: | Department of Neurosurgery, University Hospital Giessen, 35398 Giessen, Germany |
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Abstract: | Oncogenic fusion genes have emerged as successful targets in several malignancies, such as chronic myeloid leukemia and lung cancer. Fusion of the fibroblast growth receptor 3 and the transforming acidic coiled coil containing protein—FGFR3-TACC3 fusion—is prevalent in 3–4% of human glioblastoma. The fusion protein leads to the constitutively activated kinase signaling of FGFR3 and thereby promotes cell proliferation and tumor progression. The subgroup of FGFR3-TACC3 fusion-positive glioblastomas presents with recurrent clinical and histomolecular characteristics, defining a distinctive subtype of IDH-wildtype glioblastoma. This review aims to provide an overview of the available literature on FGFR3-TACC3 fusions in glioblastoma and possible implications for actual clinical practice. |
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Keywords: | FGFR3-TACC3 oncogenic fusion glioblastoma tyrosine kinase receptors FGFR TACC molecular signaling molecular diagnostics |
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