LncRNA H19 Impairs Chemo and Radiotherapy in Tumorigenesis |
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| Authors: | Carlos Garcia-Padilla,Estefaní a Lozano-Velasco,Marí a del Mar Muñ oz-Gallardo,Juan Manuel Castillo-Casas,Sheila Cañ o-Carrillo,Francisco José Martí nez-Amaro,Virginio Garcí a-Ló pez,Amelia Ará nega,Diego Franco,Virginio Garcí a-Martí nez,Carmen Ló pez-Sá nchez |
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| Affiliation: | 1.Department of Human Anatomy and Embryology, Faculty of Medicine, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, Spain; (E.L.-V.); (V.G.-L.); (V.G.-M.);2.Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain; (M.d.M.M.-G.); (J.M.C.-C.); (S.C.-C.); (F.J.M.-A.); (A.A.); (D.F.);3.Fundación Medina, 18016 Granada, Spain |
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| Abstract: | Various treatments based on drug administration and radiotherapy have been devoted to preventing, palliating, and defeating cancer, showing high efficiency against the progression of this disease. Recently, in this process, malignant cells have been found which are capable of triggering specific molecular mechanisms against current treatments, with negative consequences in the prognosis of the disease. It is therefore fundamental to understand the underlying mechanisms, including the genes—and their signaling pathway regulators—involved in the process, in order to fight tumor cells. Long non-coding RNAs, H19 in particular, have been revealed as powerful protective factors in various types of cancer. However, they have also evidenced their oncogenic role in multiple carcinomas, enhancing tumor cell proliferation, migration, and invasion. In this review, we analyze the role of lncRNA H19 impairing chemo and radiotherapy in tumorigenesis, including breast cancer, lung adenocarcinoma, glioma, and colorectal carcinoma. |
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| Keywords: | lncRNA H19 chemo-resistance radio-resistance tumorigenesis |
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