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Aberrant Splicing of INS Impairs Beta-Cell Differentiation and Proliferation by ER Stress in the Isogenic iPSC Model of Neonatal Diabetes |
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| Authors: | Alexandra V. Panova Natalia V. Klementieva Anna V. Sycheva Elena V. Korobko Anastasia O. Sosnovtseva Tatiana S. Krasnova Maria R. Karpova Petr M. Rubtsov Yulia V. Tikhonovich Anatoly N. Tiulpakov Sergey L. Kiselev |
| Affiliation: | 1.Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991 Moscow, Russia;2.Endocrinology Research Centre, 115478 Moscow, Russia;3.Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia;4.Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia |
| Abstract: | |
| Keywords: | diabetes insulin induced pluripotent stem cells CRISPR/Cas9 genome editing isogenic cell lines proliferation ER stress |