大豆异黄酮降血脂作用的研究

目的：观察大豆异黄酮对高脂血症大鼠血脂的影响.方法：选择成年雌性SD大鼠50只,体重280～320g,随机分为四组：空白对照组：喂饲基础饲料;高脂模型组：喂饲高脂饲料;其余2组分别喂饲添加300、600mg/kg大豆异黄酮的高脂饲料.实验第6周末,空腹12h,5%戊巴比妥钠麻醉后,心脏取血及制备10%肝组织匀浆,测定血清总胆固醇（TC）、甘油三脂（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、脂蛋白脂酶（LPL）、肝脂酶（HL）等指标.结果：与高脂组比较,SI剂量组大鼠肝脏中的TC、TG、LDL-C显著降低（p＜0.01）,HDL-C显著增高（p＜0.05）,LPL活性显著增强（p＜0.05）.结论：大豆异黄酮具有明显的降血脂作用.

Effects of Soy Isoflavones on Hyperlipidemia Rats

Objective: To study the influence of soy isoflavones on serum lipid level in Hyperlipidemia rats. Methods: 50 SD female rats were randomly divided in 4 groups: normal diet control, high fat diet, low dose SI (300mg/kg bw) high fat diet, and high dose SI (600mg/kg bw) high fat diet; rats of normal diet control were fed with normal diet, and rats of the remainder groups were fed with high fat diet. After 6 weeks, rats were killed and have detected serum lipid level and activity of LPL and HL in blood. Results: Compared with the group of SI diet, the TC, TG, LDL-C levels of the group of high fat diet were significantly higher, the HDL-C level were significantly lower, the activity of LPL in serum increased obviously. Conclusion: These results suggested that soy Isoflavones can decrease the serum lipid level obviously.