静电纺丝蛋白基纳米纤维的研究进展

一些生物活性物质因难溶于水且生物利用率较低而使其应用受限，近年来如何有效递送生物活性物质广受关注。然而，脂质、多糖和蛋白质作为常用的食品级载体基质在单独使用时往往存在局限性，限制了它们在递送系统中的有效性。蛋白质-脂质和蛋白质-多糖偶联是用于制造新型递送系统的新兴技术，相较于单一的一元载体，多元偶联物在体内具有更好的协同作用，在提高递送系统封装效率的同时提高整个系统的稳定低，从而最大限度地发挥产品功能性质和生物活性。本文主要综述了脂质、多糖和蛋白质作为递送系统的重要性和局限性，横向对比了单一基质与多复合载体基质之间的优缺点，蛋白质-脂质/多糖二元基质作为主要研究对象，对其偶联机制、方法及其在营养递送中的作用优势进行了探讨，并对未来的研究方向进行了展望。

Trends in encapsulation technologies for delivery of food bioactive compounds

Some bioactive substances are insoluble in water and have low bioavailability, which limits their application. In recent years, how to effectively deliver bioactive substances has attracted wide attention. However, the commonly used food-grade encapsulation carriers, lipids, polysaccharides and proteins, often have limitations when used alone, which limits their effectiveness in delivery systems. Coupling protein with lipid or polysaccharide is an emerging technology for the manufacture of new delivery systems. Compared with a single carrier, these multivariate conjugates have better synergistic effects in vivo, which improves stability and encapsulation efficiency of delivery systems, and can maximize the functional properties and biological activities of products. This paper mainly reviews the importance and limitations of lipids, polysaccharides and proteins as delivery systems, and horizontally compares the advantages and disadvantages between single matrix and multi-composite carrier matrix. The coupling of protein-lipid/polysaccharide binary matrix is taken as the main research object, and the coupling mechanism, coupling method and its advantages in nutrition delivery are discussed. The future research direction is also prospected.