壳聚糖纳米粒子的制备方法及其作为药物递送载体的应用

虾青素（Astaxanthin，AST）是一种脂溶性叶黄素类胡萝卜素，具有良好的抗氧化、抗炎和免疫调节活性。然而，因其口服生物利用度较差，临床应用有限。近年来，为了提高虾青素的生物利用度，各种类型的纳米制剂被广泛研究。其中纳米乳液、脂质体、固体脂质纳米颗粒、壳聚糖纳米颗粒和聚乳酸-羟基乙酸聚合物（poly（lactic-co-glycolic acid），PLGA）纳米颗粒已被证明可有效提高虾青素的口服生物利用度。本综述中，基于体外和体内研究数据和结果，总结了不同类型的纳米制剂对于提高虾青素口服生物利用度的研究进展，为今后虾青素口服剂型的开发提供参考，实现其在临床中的应用价值。

Optimized nonionic emulsifier for the efficient delivery of astaxanthin nanodispersions to retina: in vivo and ex vivo evaluations

Astaxanthin is a fat-soluble lutein carotenoid with good antioxidant, anti-inflammatory and immunomodulatory activities. However, its poor oral bioavailability lead to limited clinical application. Recently, in order to improve the bioavailability of astaxanthin, various types of nano-formulations have been widely studied. Nano-emulsion, liposome, solid lipid nanoparticles, chitosan and PLGA nanoparticles have been shown to effectively improve the oral bioavailability of astaxanthin. In this review, based on in vitro and in vivo studies, the research progress of nano-formulations for improving the oral bioavailability of astaxanthin are summarized, providing reference for the development of oral delivery of astaxanthin, and achieving its clinical application value in the future.