Digital microfluidic design and optimization of classic and new fluidic functions for lab on a chip systems |
| |
Authors: | Yves Fouillet Dorothée Jary Claude Chabrol Patricia Claustre Christine Peponnet |
| |
Affiliation: | (1) Department of Technology for Biology and Health, CEA-Léti-MINATEC, 17 rue des Martyrs, 38054 Grenoble, France |
| |
Abstract: | This paper deals with microfluidic studies for lab-on-a-chip development. The first goal was to develop microsystems immediately
usable by biologists for complex protocol integrations. All fluid operations are performed on nano-liter droplet independently
handled solely by electrowetting on dielectric (EWOD) actuation. A bottom-up architecture was used for chip design due to
the development and validation of elementary fluidic designs, which are then assembled. This approach speeds up development
and industrialization while minimizing the effort in designing and simplifying chip-fluidic programming. Dispensing reproducibility
for 64 nl droplets obtained a CV below 3% and mixing time was only a few seconds. Ease of the integration was demonstrated
by performing on chip serial dilutions of 2.8-folds, four times. The second part of this paper concerns the development of
new innovative fluidic functions in order to extend EWOD-actuated digital fluidics’ capabilities. Experiments of particle
dispensing by EWOD droplet handling are reported. Finally, work is shown concerning the coupling of EWOD actuation and magnetic
fields for magnetic bead manipulation. |
| |
Keywords: | Digital microfluidic Droplet Electrowetting Lab on a chip |
本文献已被 SpringerLink 等数据库收录! |