食源性血管紧张素转化酶抑制肽研究进展

肾素-血管紧张素系统（RAS）和激肽释放酶-激肽系统（KKS）在血压调节方面是一对相互拮抗的体系,其平衡失调被认为是高血压发病的一个重要因素,而血管紧张素转化酶（ACE）是影响两体系的关键。食物来源的ACE抑制肽因具有安全性好、成本低、易吸收、降压明显等优点,越来越受到人们的关注。本文详尽阐述了ACE抑制肽的降压机制、来源、生物利用率、结构与活性关系、分离纯化方法、活性测定与功能评价及其应用前景。 

Research progress in food-derived angiotensin converting enzyme inhibitory peptides

Renin-angiotensin system (RAS) and kallikrein kinin system (KKS) is a pair of mutually antagonistic system in blood pressure regulation, dissonance of which is considered to be an important factor in the pathogenesis of hypertension, and angiotensin converting enzyme (ACE) is a critical factor affecting the systems.More and more attentions have been paid to the food-derived ACE inhibitory peptides, because of their higher activity of inhibiting ACE, good security, low cost, easy to absorb and obvious antihypertension.In this review, the antihypertensive mechanism, sources, bioavailability, structure-activity relationships, separation and purification methods, activity measurement, functional assessment of ACE inhibitory peptides, and its application prospects were introduced.