| 急需开发的医药中间体--2-氰基吡嗪 |
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| 引用本文： | 朱颖,赵美法.急需开发的医药中间体--2-氰基吡嗪[J].精细与专用化学品,2002,10(11):11-12. |
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| 作者姓名： | 朱颖 赵美法 |
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| 作者单位： | 1. 山东淄博矿务局
2. 青岛天元化工股份有限公司 |
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| 摘 要： | 2-氰基吡嗪是生产治疗结核病药物吡嗪酰胺的重要原料.目前仅日本实现了2-氰基吡嗪的工业化生产,主要生产商是日本的KOEI公司.全球2-氰基吡嗪的年需求量约为2600t,年产量约为1600t,市场缺口达1000t/a.我国生产吡嗪酰胺年需求2-氰基吡嗪600t/a,而其设计能力仅为300t/a,年进口量为480t.国内近几年对2-氰基吡嗪的合成研究较多.文章还对我国2-氰基吡嗪的发展提出了建议.
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| 关 键 词： | 2-氰基吡嗪 吡嗪酰胺 医药中间体 |
2-Cyanopyrazine:A Pharmaceutical Intermediate to be Developed Urgently |
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| Zhu Ying Zhao Meifa.2-Cyanopyrazine:A Pharmaceutical Intermediate to be Developed Urgently[J].Fine and Specialty Chemicals,2002,10(11):11-12. |
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| Authors: | Zhu Ying Zhao Meifa |
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| Affiliation: | Zhu Ying Zhao Meifa |
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| Abstract: | 2-cyanopyrazine is an important raw material in manufacturing pyrazinamide, anlitubercu-lar drug. At present, only Japan has realized commercial production, KOEI is the main producer. The total demand for 2-cyanopyrazine in the world is a-bout 2600t/a,but its output is approximately 1600t/ a, short of 1000t/a. In China, the demand for 2-cyanopyrazine to produce pyrazinamide is 600t/a, design capacity is 300t/a,annual import is 480t. In recent years, more research work on 2-cyanopyrazine synthesis have been carried out at home. Some suggestions on development of 2-cyanopyrazine in China are also involved in this article. |
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| Keywords: | 2-cyanopyrazine pyrazinamide phannaceutical intermediates |
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