Rhabdomyolysis: a rare adverse effect of diphenhydramine overdose |
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Authors: | SM Emadian EM Caravati RD Herr |
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Affiliation: | Department of Neurosurgery, University of Utah Health Sciences Center, Salt Lake City 84132, USA. |
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Abstract: | Drug- and toxin-induced rhabdomyolysis is a nonspecific clinical syndrome resulting from the release of skeletal muscle cell contents into the plasma and urine. Antihistamine drugs are the active ingredients in a number of over-the-counter preparations and are frequently ingested in suicide attempts. We report rhabdomyolysis as a rare adverse effect of diphenhydramine toxicity in a 29-year-old man who ingested an unknown quantity of an over-the-counter sleep preparation in a suicide attempt. The patient had documented toxic concentration of diphenhydramine in his cerebrospinal fluid and no history of seizures, coma, or hypothermia. A high index of suspicion and an evaluation for rhabdomyolysis is warranted in antihistamine toxicity. |
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