| Abstract: | Abstract The protein desorption of human serum albumin and human fibrinogen from the surface of poly(3-hydroxybutyrate) films was studied with ATR-FTIR spectroscopy. The diffusion model for reversible and irreversible sandwiched layers was confirmed. The reversible ratio (ratio of reversible adsorbed concentration to irreversible one) registrated as a function of time allow us to propose the kinetic model of the initial stage of thromb formation. The parameters of adsorption/desorption for both proteins are compared. The reversible ratio of plasma protein adsorption is proposed as a quantitative criterion of thromb-resistance behavior for polymer in biomedicine, namely, controlled drug release vehicles, artificial vessels, magistrals, reservoirs for blood storage, and surgical threads especially. The mechanism of interaction of protein molecules with PHB macro-molecules is discussed. |
