| Abstract: | Hybrid materials with enhanced antibacterial activity were prepared by incorporation of carbon nanotubes within gelatin-fluoroquinolones bioconjugates. Gelatin bioconjugates were characterized by UV-Vis, FT-IR, and calorimetric analyses, nanohybrids by morphological analyses. Biocompatibility was evaluated on human mesenchymal stem cells, and antibacterial performance against Klebsiella pneumoniae and Escherichia coli. Minimun inhibitory concentrations from 0.025 to 0.05 µg mL?1 and from 0.025 to 0.10 µg mL?1, and MBC from 0.025 to 0.10 µg mL?1 and from 0.05 to 0.20 µg mL?1 were detected for Escherichia coli and Klebsiella pneumoniae, respectively, showing that nanotubes increase antimicrobial activity comparing to both free and gelatin-conjugated drugs. |
