2,4,4′-三羟基苯基苄酮的合成

2,4,4′-三羟基苯基苄酮是合成大豆苷元的重要中间体,也是合成大豆苷元的技术难点,工艺路线的优劣决定大豆苷元合成方法能否工业化的关键。同时它本身有非常强的抑制酪氨酸酶活性,抑制效果较好、性质稳定、对皮肤刺激小是非常有潜力的皮肤增白剂4]。本文论述了2,4,4′-三羟基苯基苄酮的合成方法,在原有文献的基础上,通过正交设计优化及反应溶剂的合理选取,提高了产品质量,降低了生产成本。

Synthesis of 2,4,4'-Trihydroxydroxydeoxybenzoin

Synthesis of 2,4,4′-trihydroxydroxydeoxybenzoin was an important intermediate of daidzein,and also the technical difficulties of synthesis of daidzein.The decision of merits of process route synthesis of daidzein was the key to industrialization.While itself had a very strong inhibition of tyrosinase activity,and the inhibition was better,stable,and small stimulation to skin,so it was a very promising small skin brightener4].Synthesis method of 2,4,4′-trihydroxydroxydeoxybenzoin was introduced.On the basis of the existing literature,through optimized orthogonal design and appropriate selection of solvents,the product quality was improved and production cost was reduced.