| D-樟脑-10-磺酸拆分西布曲明及其中间产物的研究 |
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| 引用本文： | 谭思师,王朝阳. D-樟脑-10-磺酸拆分西布曲明及其中间产物的研究[J]. 安徽化工, 2008, 34(1): 26-28 |
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| 作者姓名： | 谭思师 王朝阳 |
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| 作者单位： | 西南科技大学生命科学与工程学院,四川,绵阳,621010;西南科技大学生命科学与工程学院,四川,绵阳,621010 |
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| 摘 要： | 以D-樟脑-10-磺酸与西布曲明作为起始原料,用D-樟脑-10-磺酸拆分西布曲明.西布曲明与D-樟脑-10-磺酸在乙酸乙酯中成盐后,得到非对映异构体盐.通过红外、核磁对中间产物进行表征,证实中间产物为未见报道化合物.纯化后用饱和Na2CO,溶液处理,用乙醚溶解,旋转蒸发之后得到左旋西布曲明,拆分收率23.6%.
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| 关 键 词： | D-樟脑-10-磺酸 西布曲明 拆分 |
| 文章编号： | 1008-553X（2008）01-0026-03 |
| 收稿时间： | 2007-09-30 |
| 修稿时间： | 2007-09-30 |
The Research on Resolution of Sibutramine and Intermediate by D-Camphor-10-Sulfonic Acid |
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| TAN Si-shi,WANG Zhao-yang. The Research on Resolution of Sibutramine and Intermediate by D-Camphor-10-Sulfonic Acid[J]. Anhui Chemical Industry, 2008, 34(1): 26-28 |
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| Authors: | TAN Si-shi WANG Zhao-yang |
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| Abstract: | D-camphor-10-sulfonic acid and was used as the initial material to resolute sibutrmine . The diastereomer salt was formed by reacting D-camphor-10-sulfonic with sibutramine in the ethyl acetate. The salt was purified and then disposed by saturation of Na2CO3. Then product was obtained by vaporizing. And resolution yield was 23.6%. The diastereomer salt structure was confirmed through IR,1HMNR. |
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| Keywords: | D-camphor-10-sulfonic acid Sibutrmine resolution |
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