Neural network based non-invasive method to detect anemia from images of eye conjunctiva

Detection of anemia can be done by examining the hemoglobin concentration level in the blood using complete blood count, which is an invasive, time-consuming, and costly technique. Preliminary methods for detecting anemia include examining the color of the palpebral conjunctiva, which is a non-invasive method, but color perception may vary from person to person. This study aims to develop a computerized non-invasive technique for anemia detection. We propose a novel machine learning model using the artificial neural network to detect anemic patients from the images of eye conjunctiva. Since limited and small dataset has been used in the earlier approaches, this may cause over fitting of the model. We have improved the number of available training images using image augmentation techniques. To standardize a non-invasive method, we have used computer vision algorithms for preprocessing and feature extraction. This article derives the backpropagation rules mathematically for adjusting the weights for the proposed neural network model. After hyper parameter tuning and using the mathematically derived backpropagation rules, the model was able to achieve the best accuracy of 97.00% with sensitivity 99.21% and specificity 95.42% on the created dataset.