Increments of dietary linoleate raise liver arachidonate,but markedly reduce heart n−6 and n−3 fatty acids in the rat |
| |
Authors: | Franca Marangoni Cristina Mosconi Gerardina Galella Claudio Galli |
| |
Affiliation: | (1) Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milano, Italy |
| |
Abstract: | Four diets containing 20% of energy (en%) as fat and with linoleic acid contents of 1.9, 3.1, 7.7 and 10.1 en%, respectively, were fed to one-month-old male rats for three months. The fatty acid profiles and the levels of the major n−6 and n−3 fatty acids in the lipids of plasma, liver, heart and kidney were measured. We found that with increasing concentrations of 18∶2n−6 in the diet, linoleic acid rose in plasma and in all organs, but long-chain n−6 and n−3 fatty acids responded differently. In liver, arachidonic acid increased and n−3 fatty acids were not significantly affected; in heart, both arachidonic and docosahexaenoic acids were progressively reduced; and in kidney, there was no change of n−6 and n−3. The results indicate that incremental changes in dietary, linoleate affect the levels of polyunsaturated fatty acids in liver and extrahepatic organs differently. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|