| 18F-FDG符合显像诊断梗死心肌活力的实验研究 |
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| 引用本文： | 许长德,陈绍亮,姚瑞敏,张庆勇,石洪成. 18F-FDG符合显像诊断梗死心肌活力的实验研究[J]. 核技术, 2006, 29(5): 372-375 |
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| 作者姓名： | 许长德 陈绍亮 姚瑞敏 张庆勇 石洪成 |
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| 作者单位： | 复旦大学附属中山医院核医学科,上海,200032 |
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| 摘 要： | 将6只20kg的小型猪制作心肌梗死模型,进行心肌99Tcm-甲氧基异丁基异腈(99Tcm-sestamibi,99Tcm-MIBI)血流灌注显像确定梗死区,用18F-脱氧葡萄糖(18F-fluorodeoxyglucose,18F-FDG)观察空腹与糖负荷图像的差别,确定心肌坏死或存活区.制作模型前进行自身对照形成对照组.并进行B超心功能检查.结果显示:心肌梗死区大部分心肌没有活力,99Tcm-MIBI和18F-FDG都没有摄取.空腹时有部分心肌显影,糖负荷时该区域显影程度减轻.
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| 关 键 词： | 18F-脱氧葡萄糖 99Tcm-甲氧基异丁基异腈 心肌活力 |
| 收稿时间： | 2004-04-19 |
| 修稿时间： | 2004-04-192004-12-18 |
18F-FDG coincidence imaging diagnosis of viability of infarction myocardium |
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| XU Changde,CHEN Shaoliang,YAO Ruimin,ZHANG Qingyong,SHI Hongcheng. 18F-FDG coincidence imaging diagnosis of viability of infarction myocardium[J]. Nuclear Techniques, 2006, 29(5): 372-375 |
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| Authors: | XU Changde CHEN Shaoliang YAO Ruimin ZHANG Qingyong SHI Hongcheng |
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| Affiliation: | Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032 |
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| Abstract: | The objective of the work is to observe the role of 99Tcm-sestamibi perfusion imaging and coincidence imaging with 18F-FDG for detecting viability of infarct myocardum in miniswine model. Six minipigs with circum- flex branch ligation for the myocardial infarction underwent excising and resting myocardial perfusion imaging with 99Tcm-MIBI by using single photon emission computed tomography (SPECT) and fast and glucose-injection coinci- dence imaging with 18F-FDG. They also underwent the imaging before operation as a normal control group. The re- gion of myocardial infarction of the model was found no uptake of the 99Tcm-MIBI and 18F-FDG. Part myocardium can be imaged in fast state, and after injecting 18F-FDG the images in this region get fainter. It is concluded that the coincidence imaging with 18F-FDG is better to diagnose the viability of infarct myocardium, and fast and glucose stress can display viability of severe ischmia myocardium. |
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| Keywords: | ^18F-FDG ^99Tc^m-MIBI Myocardium viability |
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