| 番荔枝宁合成工艺研究 |
| |
| 引用本文： | 郭新艳,姜申德.番荔枝宁合成工艺研究[J].精细化工,2010,27(9). |
| |
| 作者姓名： | 郭新艳 姜申德 |
| |
| 作者单位： | 天津大学,天津大学 |
| |
| 摘 要： | 以3,4-二甲氧基苯乙腈为起始原料，分别制备3,4-二甲氧基苯乙胺和3,4-二甲氧基苯乙酸，二者经酰化，Bischler-Napieralski环化，硼氢化钾还原制得中间体四氢罂粟碱，后同甲醛经Pictet-Spengler反应制得(±)-番荔枝宁。该方法合成番荔枝宁的总收率为47％。
|
| 关 键 词： | 番荔枝宁 生物碱 四氢罂粟碱 |
| 收稿时间： | 2010/6/13 0:00:00 |
| 修稿时间： | 2010/6/21 0:00:00 |
Ths Synthesis of Xylopinine |
| |
| GUO Xin-yan and JIANG Shen-de.Ths Synthesis of Xylopinine[J].Fine Chemicals,2010,27(9). |
| |
| Authors: | GUO Xin-yan and JIANG Shen-de |
| |
| Affiliation: | School of Pharmaceutical Science and Technology |
| |
| Abstract: | 3,4-Dimethoxyphenylacetonitrile was employed as the staring material to give 3,4-dimethoxyphenylethylamine and 3,4-dimethoxyphenylacetic acid via hydrolysis and hydrogenation reduction, respectively. The resulting two intermediates were reacted to produce the amide, which underwent Bischler-Napieralski cyclization, potassium borohydride reduction, and Pictet-Spengler reaction with formaldehyde to give racemic xylopinine in an overall yield of 47%. |
| |
| Keywords: | xylopinine alkaloid tetrahydropapaverine |
|
| 点击此处可从《精细化工》浏览原始摘要信息 |
|
点击此处可从《精细化工》下载全文 |
|
