Involvement of cholinergic system in losartan-induced facilitation of spatial and short-term working memory |
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Authors: | V Raghavendra K Chopra SK Kulkarni |
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Affiliation: | Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. |
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Abstract: | In the present study we have shown the potential memory enhancing property of losartan, a selective Ang II AT1 receptor antagonist. Nootropic activity of losartan in mice was assessed by using passive avoidance step-down task and elevated plus-maze as a measure of short-term working and spatial memory respectively. Losartan at higher dose (10 mg/kg i.p) improved the basal performance in retention testing in both the test paradigms. Prior administration of losartan also attenuated retention deficit induced by scopolamine (0.3 mg/kg i.p). Moreover, physostigmine (0.05 mg/kg i.p) potentiated memory enhancing properties of losartan administered at lower dose (5 mg/kg i.p). On the basis of above observations it is concluded that the memory enhancing properties of losartan can be attributed to increased cholinergic activity. |
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