| N—琥珀酰亚胺[2,3—^3H]丙烯酸酯的合成 |
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| 引用本文： | 张作恩 李志敏. N—琥珀酰亚胺[2,3—^3H]丙烯酸酯的合成[J]. 核技术, 1989, 12(12): 747-749 |
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| 作者姓名： | 张作恩 李志敏 |
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| 作者单位： | 军事医学科学院毒物药物研究所(张作恩，李志敏)，军事医学科学院毒物药物研究所(龚雄麒) |
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| 摘 要： |
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| 关 键 词： | 氚标记 试剂 氢谱 丙烯酸酯 合成 |
Preparation of N-succ nimidyl (2,3-3H) propionate |
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| Zhang Zuoen Li Zhimin Gong Xiongqi. Preparation of N-succ nimidyl (2,3-3H) propionate[J]. Nuclear Techniques, 1989, 12(12): 747-749 |
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| Authors: | Zhang Zuoen Li Zhimin Gong Xiongqi |
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| Abstract: | 3H-NSP is current important reagent for introduction of tritium into proteins and polypeptide. The precursor, N-succinimidyl acrylate was obtained by the reaction of acrylic acid with N-hydroxysuccinimide in the presence of DCC and it was tritiated with tritium gas in the presence if 10% Pd-C catalyst. The crude product was purified by silica gel chromatography. The radiochemical purity and specific activity were-95% and 1.35 TBq/mmol respectively. |
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| Keywords: | Tritium N-succinimidyl acrylate 3H-NSP |
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