Semi-quantitative approach to estimating GFR by magnetic resonance imaging |
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Authors: | Hidemasa Uematsu Tetsuya Matsuda Tatsuro Tsuchida Hiroshi Inoue Koji Hayashi Yoshiharu Yonekura Harumi Itoh |
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Affiliation: | (1) Department of Radiology, Fukui Medical University, 23 Shimoaizuki, Matsuoka-cho, Yoshida-gun, 910-1193 Fukui, Japan;(2) Department of Medical Informatics, Kyoto University Hospital, Kyoto, Japan;(3) Department of Radiology, Rakuwakai Otowa Hospital, Kyoto, Japan;(4) Biomedical Imaging Research Center, Fukui Medical University, Fukui, Japan |
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Abstract: | Objective: The purpose of this study was to compare a semi-quantitative approach to estimating glomerular filtration rate (GFR) by
magnetic resonance imaging with radionuclide calculation of GFR, and to investigate whether spin echo or gradient echo is
more suitable for estimating GFR.Methods and patients: Fourteen kidneys of seven patients (GFR ranging from 26 to 57 ml/min) were studied. Spin echo and gradient echo sequences
interleaving each other at every excitation were used. After intravenous injection of gadopentetate dimeglumine, serial scans
were performed. The signal intensities measured in the regions of interest were converted to time-transverse relaxation rate
changes for both spin echo (ΔR2) and gradient echo (ΔR2*). The areas under the time-ΔR2 and time-ΔR2* curves were calculated as a semi-quantitative index of GFR for both spin echo and gradient echo images, and the results were
compared by GFR measured by radionuclide imaging.Results: The semi-quantitative index of the GFR calculated from spin echo images showed a significant correlation with the GFR measured
by radionuclide imaging (r=0.85,P<0.001). On the other hand, the semi-quantitative index of the GFR calculated from gradient echo images showed no such correlation
(r=0.46,P=0.10).Conclusion: Spin echo sequences may be more suitable than gradient echo sequences for the evaluation of GFR. |
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Keywords: | Magnetic resonance imaging Renal function Spin echo Gradient echo Renography Glomerular filtration rate |
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