基材与液晶种类对液晶复合膜血液相容性的影响

从仿生学的角度设计和制备结构及组成与生物膜及血管内壁相似的聚合物/液晶复合膜,作为新一类抗凝血生物材料,并通过血液相容性试验考察复合材料的抗凝血性能.结果显示:不同基材及液晶种类的聚合物/液晶复合膜,其溶血率值均小于5%,符合生物材料溶血试验的要求;复合膜的动态凝血性能取决于基材与液晶两者之间的兼容性及配比,动态凝血性能较佳的复合膜表面粘附的血小板大多呈单个粘附状态,数量较少,且基本无变形,呈现出良好的血液相容性.

Effect of Types of Base Materials and Liquid Crystals on the Blood Compatibility of LC Composite Membranes

In this work, as a new type of biomaterial preventing blood coagulation and clot, polymer/LC composite membranes were designed and prepared according to the principle of bionics. The anti-coagulation and clot properties of membranes were evaluated by the blood compatibility tests. The results showed that the haemolysis ratio of membranes prepared by different species of polymer and LCs were lower than 5%, conforming to the HR value of biomaterials. The property of dynamic blood cloting was influenced by the compatibility and the ratio between base materials and liquid crystals. The better was the property of dynamic blood clotting, the less were the degree of platelets adhesion and spreading on the membranes surfaces.