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Quantitative susceptibility mapping in a diabetes mellitus rat model: Iron accumulation in the brain |
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| Authors: | Soo‐Young Yoon Soonchan Park Hyug‐Gi Kim Tae‐Hee Park Sun Mi Kim You‐Cheol Hwang Gou Young Kim Chang‐Woo Ryu Tai‐Young Yoon Geon‐Ho Jahng |
| Affiliation: | 1. Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, 892 Dongnam‐ro, Gangdong‐gu, Seoul, Republic of Korea;2. Department of Biomedical Engineering, Graduate School, Kyung Hee University, 1732 Deogyeong‐daero, Giheung‐gu, Yongin‐si, Gyeonggi‐do, Republic of Korea;3. Department of Medicine, Graduate School, Kyung Hee University, 26 Kyunghee‐daero, Dongdaemun‐gu, Seoul, Republic of Korea;4. Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, 892 Dongnam‐ro, Gangdong‐gu, Seoul, Republic of Korea;5. Department of Pathology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, 892 Dongnam‐ro, Gangdong‐gu, Seoul, Republic of Korea;6. Department of Preventive Medicine, College of Medicine, Kyung Hee University, 26 Kyunghee‐daero, Dongdaemun‐gu, Seoul, Republic of Korea |
| Abstract: | This study evaluated the susceptibility effects using quantitative susceptibility mapping (QSM) as a marker for regional brain iron alternations in diabetic rat brains. Otsuka Long‐Evans Tokushima Fatty (OLETF) rats (n = 7) and age‐matched lean Long‐Evans Tokushima Otsuka (LETO) control rats (n = 8) were scanned using a three‐dimensional gradient‐echo sequence in a 3 Tesla MRI to map QSM. The correlation analysis was performed to evaluate the relationship between the QSM value and the body weight and the fasting blood glucose value of the rats. QSM values in the OLETF group were significantly increased in hippocampi and thalami, as compared with those of the LETO group. The QSM values of the OLETF rats were negatively correlated with the body weight in putamen and were significantly correlated with the fasting blood glucose level in the left amygdala and right thalamus. With higher QSM values in diabetic rats than in control rats, QSM values in the diabetic group were significantly correlated with the body weight and the fasting blood glucose level, indicating that the QSM technique should be helpful to noninvasively investigate iron overload in the diabetic brain. |
| Keywords: | quantitative susceptibility mapping diabetes rat brain iron accumulation |