Comparison of regional cerebral blood flow in Parkinson's disease with depression and major depression |
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| Authors: | Young‐Do Kim Hyeonseok S Jeong Yong‐Duk Kim |
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| Affiliation: | 1. Department of Neurology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea;2. Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea;3. Department of Neurology, College of Medicine, Konyang University, Daejeon, South Korea |
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| Abstract: | Diagnosis of depression in Parkinson's disease (PD) patients is complicated due to the overlapping symptoms of the two disorders. We investigated regional cerebral blood flow (rCBF) in patients with only major depression (MD) and PD patients with (PDMD) and without MD (PDNMD) using 99mTc hexamethylpropyleneamine oxime single photon emission computed tomography (HMPAO‐SPECT). A total of 103 patients (38 PDMD, 46 PDNMD, and 19 MD patients) underwent brain HMPAO‐SPECT scans. Voxel‐wise whole‐brain analysis was conducted to compare rCBF of the PDMD group with that of the PDNMD and MD groups. The scores of the Geriatric Depression Scale (GDS) and Neuropsychiatric Inventory (NPI) were significantly higher in the PDMD group than in the PDNMD group. The PDMD group showed significant hypoperfusion in the subcallosal cortex than the PDNMD group. The MD group showed significant hypoperfusion in the brainstem and inferomedial frontal region compared with the PDMD group. Our findings suggest that dysfunction of the inferomedial frontal cortex may be involved in the pathogenesis of depression in PD patients. |
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| Keywords: | depression Parkinson's disease regional cerebral blood flow single photon emission computed tomography |
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