诺卜二烯的合成及应用研究进展

综述了诺卜二烯的合成方法及其在精细化工和有机合成中的应用。利用诺卜醇直接脱水反应、诺蒎酮的格氏反应、诺卜基醚或诺卜基磺酸酯的消去反应、硫代苯甲酸诺卜酯的光催化消去反应及桃金娘烯醛的Wittig反应等几种方法能够合成得到诺卜二烯。含共轭双键的诺卜二烯可直接用作精细化工配方成分,更多的是经过Diels-Alder反应用于合成香料、手性配体等物质,或者与含亲电基团的化合物反应合成一系列衍生物,或者作为单体合成聚合物产品。

Research Progress on Synthesis and Application of Nopadiene

The synthesis and application of nopadiene in fine chemicals as well as in organic synthesis were reviewed. Nopadiene could be synthesized by the direct dehydration of nopol, the elimination of nopyl ethers or nopyl tosylate, the photo-degradation of nopyl thiobenzoic acid o-esters, and the reaction of nopinone with Grignard reagent, etc. Nopadiene with two conjugated double bonds can be applied as a fine chemical composition. However, the more nopadiene is applied to synthesize perfume, chiral ligand compounds through Diels-Alder reactions, or to synthesize some other related compounds through reactions with electrophilic groups, or to be polymerized as a monomer.