| 药物在丝素膜中释放动力学参数的测定 |
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| 引用本文： | 田保中,张幼珠,吴徵宇,徐帼英. 药物在丝素膜中释放动力学参数的测定[J]. 苏州大学学报(工科版), 2000, 20(4): 9-13 |
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| 作者姓名： | 田保中 张幼珠 吴徵宇 徐帼英 |
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| 作者单位： | 苏州大学材料工程学院,江苏,苏州,215021 |
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| 摘 要： | 介绍了一种测定药物释放动力学参数的方法 ,并测定了洗必泰 (Hibitane)和磺胺嘧啶银SD -Ag)的渗透系数P、扩散系数D和膜 -液分配系数K ,为研究药物在丝素膜中的释放动力学规律打下了基础。
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| 关 键 词： | 洗必泰 磺胺嘧啶银 丝素膜 释放动力学参数 |
| 修稿时间： | 2000-05-03 |
MEASUREMENT AND DETERMINATION OF RELEASE DYNAMICS PARAMETERS OF DRUGS IN FIBROIN MEMBRANE |
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| TIAN Bao-zhong,ZHANG You-Zhu,WU Zheng-yu,XU Gou-ying. MEASUREMENT AND DETERMINATION OF RELEASE DYNAMICS PARAMETERS OF DRUGS IN FIBROIN MEMBRANE[J]. Journal of Suzhou University(Engineering Science Edition), 2000, 20(4): 9-13 |
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| Authors: | TIAN Bao-zhong ZHANG You-Zhu WU Zheng-yu XU Gou-ying |
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| Abstract: | A method was introduced to measure and determine drug release dynamics parameters form fibroim membrane (FM). Permeating coefficient P, diffusion coefficient D and distribution coefficient K (between FM and solution) of Hibitane and SD Ag were separately measured and determined, which laid a good foundation for the research on release dynamics of drugs in FM. |
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| Keywords: | hibitane SD Ag fibroin membrane release dynamics parameter |
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