3种金缕梅科植物提取物对动物皮肤防护研究

通过抑菌、热板镇痛、抗炎、皮肤刺激性和强紫外线辐射实验，研究了江西野生金缕梅、橙木、枫香3种金缕梅科植物的乙酸乙酯提取物对小鼠皮肤综合防护作用。实验结果表明：对实验菌株有抑制作用，明显提高小白鼠痛阈，能极显减少二甲苯所致的小白鼠耳廓炎症肿胀度；在实验浓度范围内对皮肤无刺激性和过敏反应，外涂能明显降低组织中因强紫外线辐射产生的丙二醛的含量；该3种金缕梅科植物的乙酸乙酯提取物对皮肤具有抑菌、镇痛、抗炎和减轻紫外线照射引起的自由基损伤等综合防护作用。

Experimental study of protection animals skin of three wild hamamelidaceae plants extract

Three kinds of wild plant grown in Jiangxi province,namely Hamamelis mollis,Corylopsis sinensis and Liquidambar formosana were studied for their comprehensive protection effects on the skin of guinea-pigs.Samples of the plants were extracted using ethyl acetate as solvent and the extracts were treated separately by a series of tests,including bacteria (restraining) test,hot plate pain threshold test,anti-inflammation test,skin irritative test and strong UV irradiation test.The experimental results indicate that the extract has restraining effect on the bacteria used in the experiment,can enhance markedly the guinea's pain threshold,can alleviate the inflammation of guinea pig's ears induced by dimethylbenzene remarkablely.There were no skin irritative and allergic reactions under the experimental conditions.Smearing the extraction content could significantly reduce the concentration of malondialdehyde in UV irradiation induced in the guinea's skin.Obviously,the extract from these three plants using ethyl acetate as solvent have good comprehensive protection effects on restraining bacteria,analgesia,anti-inflammation and alleviate free radicals injury of guinea pig's skin resulted from UV irradiation.