MR monitoring of tumour thermal therapy |
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Authors: | D Germain P Chevallier A Laurent H Saint-Jalmes |
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Affiliation: | 1. Centre de Recherche en Imagerie Interventionnelle (Cr2i, APHP-INRA), Domaine de Vilvert, 7S352, Joiiy en Jams, France 2. Marconi Medical Systems France, Chatenay-Malahry, France 3. Service d’imagerie médicale, H?pital de l’Archet 2, Nice, France 4. H?pital Lariboisière, Paris, France 5. Laboratoire de RMN, UMR 5012-CNRS, Université Claude Bernard-Lyon I, Lyon, France
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Abstract: | Thermal therapy of tumour including hyperthermia and thermal ablation by heat or cold delivery requires on line monitoring.
Due to its temperature sensitivity, Magnetic Resonance Imaging (MRI) allows thermal mapping at the time of the treatment.
The different techniques of MR temperature monitoring based on water proton resonance frequency (PRF), longitudinal relaxation
time Tl, diffusion coefficient and MR Spectroscopic Imaging (MRSI) are reviewed and debated. The PRF method appears the most
widely used and the most efficient at high magnetic field in spite of important drawbacks. The Tl method is the easiest method
of visualisation of qualitative temperature distribution and quantitative measurement seems possible in the tissue surrounding
the tumour up to a temperature of 45–65°C. Despite its high temperature sensitivity, application of the diffusion method in
vivo is restricted due to its high motion sensitivity. The recent MRSI technique seems very promising provided acquisition
times can be reduced. Results from the literature indicate that MR temperature monitoring in vivo can be achieved in vivo
with a precision of about 3°C in 13 s for a voxel of 16 mm3 (1.5 × 1.5 × 7 mm) in 1.5 T scanners. |
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Keywords: | Interventional MRI MR monitoring Temperature Interstitial thermal therapy: Hyperthermia Thermal ablation |
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