Chemical synthesis of {gamma}-echistatin analogues: elucidation of status of C-terminal (45-49) |
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| Authors: | Chen Pei-Yeh; Wu Shih-Hsiung; Wang Kung-Tsung |
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| Affiliation: | Institute of Biological Chemistry, Academia Sinica and Institute of Biochemical Sciences, National Taiwan University PO Box 23 – 106, Taipei, Taiwan |
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| Abstract: | Three analogues of  -echistatin, des(45–49)--echistatin,des(46–49)-y-echistatin and des(47–49)--echistatin,were synthesized by solid-phase methodology and their biologicalactivities were measured and compared. The results reveal thatwithout the C-terminal (45–49) of -echistatin, the foldingof the protein to the final active structure is not interferedwith and Lys-45 influences the inhibition of platelet aggregation. |
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| Keywords: | dismtegrin/ echistatin/ platelet aggregation/ solid-phase peptide synthesis |
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