| 4-色满酮曼尼希碱类化合物的合成及其抗血小板聚集活性 |
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| 引用本文： | 胡春,邱志远,王永永,肖高铿,宋丽焱,庞雁.4-色满酮曼尼希碱类化合物的合成及其抗血小板聚集活性[J].精细化工中间体,2010,40(2):18-21,40. |
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| 作者姓名： | 胡春 邱志远 王永永 肖高铿 宋丽焱 庞雁 |
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| 作者单位： | 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
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| 摘 要： | 4-色满酮类化合物具有广泛的生物活性。为了考察4-色满酮类化合物的抗血小板聚集活性构效关系,笔者设计合成了10种4-色满酮Mannich碱类化合物,其组成和结构经熔点、红外光谱和核磁共振氢谱确证,其中6个(5d～5g,5i～5j)目标化合物均未见文献报道。采用Born's比浊法对目标化合物进行了抗血小板聚集活性的体外筛选,实验结果表明,目标化合物对二磷酸腺苷(ADP)诱导的家兔血小板聚集均具有显著的体外抑制活性。
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| 关 键 词： | 4-色满酮 衍生物 合成 抗血小板聚集 |
Study on Synthesis and Anti-platelet Aggregative Activity of the Mannich Base Derivatives of 4-Chromanones |
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| HU Chun,QIU Zhi-yuan,WANG Yong-yong,XIAO Gao-keng,SONG Li-yan,PANG Yan.Study on Synthesis and Anti-platelet Aggregative Activity of the Mannich Base Derivatives of 4-Chromanones[J].Fine Chemical Intermediates,2010,40(2):18-21,40. |
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| Authors: | HU Chun QIU Zhi-yuan WANG Yong-yong XIAO Gao-keng SONG Li-yan PANG Yan |
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| Affiliation: | (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China) |
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| Abstract: | 4-Chromanones are known to exhibit a wide range of biological activities. In order to study the structure-activity relationships of anti-platelet aggregative activity of 4-chromanone derivatives,Ten Mannich bases of 4-chromanone derivatives were designed, synthesized and characterized, among which compounds （5d-5g, 5i-5j） were reported for the first time. The anti-platelet aggregative activity of the target compounds was tested using Born＇s method. Results revealed that all the target compounds showed good inhibitory activities against rabbit platelet aggregation induced by ADP in vitro. |
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| Keywords: | 4-chromanone derivatives synthesis anti-platelet aggregative activity |
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