| 甲磺酸多沙唑嗪的合成 |
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| 引用本文： | 王春风,应会荣,蒋成君.甲磺酸多沙唑嗪的合成[J].浙江化工,2009,40(2):1-3. |
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| 作者姓名： | 王春风 应会荣 蒋成君 |
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| 作者单位： | 1. 浙江新东港药业股份有限公司,浙江,台州,318000
2. 浙江科技学院生物与化学工程学院,浙江,杭州,310023 |
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| 摘 要： | 丙烯酸乙酯经溴化，与邻苯二酚环合，哌嗪化，成盐制得中间体1-（1,4-苯并二噁烷-2-甲酰基）哌嗪盐酸盐。该中间体与2-氯-4-氨基-6，7-二甲氧基喹唑啉反应制得盐酸多沙唑嗪，再与甲磺酸反应得甲磺酸多沙唑嗪，对反应溶剂进行选择，在最优溶剂条件下，总收率为29．7％，该方法工艺简单，适用于工业化生产。
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| 关 键 词： | 多沙唑嗪 抗高血压药 甲磺酸 |
Synthesis of Dexazosin Mesylate |
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| WANG Chun-feng,Yin Hui-rong,JIANG Cheng-jun.Synthesis of Dexazosin Mesylate[J].Zhejiang Chemical Industry,2009,40(2):1-3. |
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| Authors: | WANG Chun-feng Yin Hui-rong JIANG Cheng-jun |
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| Affiliation: | WANG Chun-feng ,Yin Hui-rong ,JIANG Cheng-jun (1.Zhejiang Neo-Dankong Pharmaceutical Co., Ltd., Taizhou 318000,China; 2.School of Biological and Chemical Engineering,Zhejiang University of Science and Technology, Hangzhou 310023,China) |
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| Abstract: | The intermediate （1,4-benzdioxazolyl-2-formyl）piperazine were prepared from catechol by cyclization, amination. Mesylate doxazosin was synthesized from doxazosin hydrochloride which prepared by condensing the intermediate with 2-chloro-4-amino--6,7-dimethoxyquinazoline. The yield of the product was 29.7%, and the synthetic route was easy to operate and suitable for industrialization. |
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| Keywords: | doxazosin synthesis catechol |
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