| 比卡鲁胺中间体4-氨基-2-三氟甲基苯腈的合成 |
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| 引用本文： | 谢媛,陈宏博,张同斌. 比卡鲁胺中间体4-氨基-2-三氟甲基苯腈的合成[J]. 精细化工中间体, 2012, 42(5): 40-42,47 |
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| 作者姓名： | 谢媛 陈宏博 张同斌 |
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| 作者单位： | 大连理工大学化学学院,辽宁大连,116023 |
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| 摘 要： | 以间氟三氟甲苯为原料,经溴化反应、格氏反应、氰化反应和氨化反应,合成了4-氨基-2-三氟甲基苯腈,总收率达49.2%。用质谱(MS)、红外光谱(IR)和核磁共振氢谱(1H NMR)确定了目标化合物的结构。该方法绿色环保,操作简单易行,具有工业化应用前景。
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| 关 键 词： | 4-氨基-2-三氟甲基苯腈 比卡鲁胺 中间体 合成 |
Synthesis of 4-Amino-2-(trifluoromethyl)benzonitrile-an Intermediate for Bicalutamide |
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| XIE Yuan , CHEN Hong-bo , ZHANG Tong-bin. Synthesis of 4-Amino-2-(trifluoromethyl)benzonitrile-an Intermediate for Bicalutamide[J]. Fine Chemical Intermediates, 2012, 42(5): 40-42,47 |
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| Authors: | XIE Yuan CHEN Hong-bo ZHANG Tong-bin |
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| Affiliation: | (College of Chemistry,Dalian University of Technology,Dalian 116023,China) |
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| Abstract: | 4-Amino-2-(trifluoromethyl)benzonitrile,an intermediate for the synthesis of bicalutamide,was synthesized from m-fluoro-(trifluoromethyl)benzene via bromination,Grignard reaction,cyanidation and amination in overall yield of 49.2%.Its structure was confirmed by MS,IR and 1H NMR.In summary,an environmentally friendly practical method has been developed. |
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| Keywords: | 4-amino-2-(trifluoromethyl)benzonitrile Bicalutamide intermediate synthesis |
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