Predicting gas chromatographic separation and stationary-phase selectivity using computer modeling |
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Authors: | Dorman Frank L Schettler Paul D English Christopher M Patwardhan Dinesh V |
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Affiliation: | Restek Corporation, Bellefonte, Pennsylvania 16823, USA. |
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Abstract: | A computer modeling technique has been developed which allows for the prediction of chromatographic separation and stationary-phase selectivity. This technique enables development of application-specific gas chromatographic columns by allowing for the simultaneous optimization of physical dimensions, flow and temperature programs, and stationary-phase composition. Stationary-phase selectivity is the most powerful tool available to achieve a separation; however most commercially available columns were not designed to have a selectivity specific to the separations for which they are used. The techniques described in this paper were developed to address this need. |
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