| 冻干麻疹活疫苗的热稳定性观察 |
| |
| 引用本文： | 方捍华 王晓新. 冻干麻疹活疫苗的热稳定性观察[J]. 中国生物制品学杂志, 1993, 6(2): 79-81 |
| |
| 作者姓名： | 方捍华 王晓新 |
| |
| 作者单位： | 中国药品生物制品检定所，中国药品生物制品检定所，中国药品生物制品检定所 北京 100050，北京 100050，北京 100050 |
| |
| 摘 要： | 对国产冻干麻疹活疫苗进行了加速热稳定性试验,结果在37℃、41℃及45℃的下降率分别为0.0245。0.0599及0.1 435 TCID_(50)/ml/天,三者差异十分显著;半衰期分别为12.3天。5.0天及2.1天,表明疫苗的稳定性有所提高,但与文献报道的差距尚大,比较不同基础滴度疫苗在37℃下的热稳定性,结果下降率及半衰期未见明显差异。
|
| 关 键 词： | 麻疹活疫苗 稳定性 下降率 半衰期 |
Study on Thermostability of Freeze-dried Live Measles Vaccine |
| |
| Fang Hanhuan National Institute for the Control of Pharmaceutical and Biological Products,Beijing. Study on Thermostability of Freeze-dried Live Measles Vaccine[J]. Chinese Journal of Bilogicals, 1993, 6(2): 79-81 |
| |
| Authors: | Fang Hanhuan National Institute for the Control of Pharmaceutical Biological Products Beijing |
| |
| Abstract: | The thermostability of freeze-dried measles live vaccine was studied by accelerated thermostability tests. The results showed that the descending rates of thermostability of vaccine were 0. 0245, 0. 0599 and 0. 1435 TCID_(50)/day at 37℃, 41℃ and 45℃, respectively, and the half life periods of the vaccine were 12. 3 days, 5. 0 days and 2. 1 days at the three temperature, respectively. There was no significant difference between the descending rate and half life periods of high-titer measles vaccine and low-titer measles vaccine. It suggested that the thermostability of domestic vaccines was improved, but still had a great disparity compared with relevant documented record. |
| |
| Keywords: | Measles Stability Degradation rate Half life periods |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
