| Electrospinning of curcumin loaded chitosan/poly （lactic acid） nanofilm and evaluation of its medicinal characteristics |
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| 作者姓名： | Bhaarathi DHURAI Nachimuthu SARASWATHY Ramasamy MAHESWARAN Ponnusamy SETHUPATHI Palanisamy VANITHA Sukumar VIGNESHWARAN~ and Venugopal RAMESHBABU |
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| 作者单位： | [1]Department of Textile Technology, Kumaraguru College of Technology, Coimbatore 641049, Tamilnadu, India [2]Department of Biotechnology, Kumaraguru College of Technology, Coimbatore 641049, Tamilnadu, India |
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| 基金项目： | We thank Department of Biotechnology, Ministry of Science and Technology, Government of India, New Delhi for the Financial Support, Grant No. BT/PRI3682/MED/32/140/2010. |
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| 摘 要： | The curcumin loaded chitosanlpoly （lactic acid） （PLA） nanoflbers were produced using electrospinning. Box-Behnken experimental design was used for the optimization of variables （-1, 0, ＋ 1 coded level） like chitosan/PLA strength （% w/v）, curcumin strength （% w/v） and applied voltage （kV） to obtain uniform fiber diameter. The morphology of nanofibers was shown by SEM. Molecular interactions and the presence of each chemical compound of curcumin loaded chitosanlPLA fibers were characterized by FTIR and EDX analysis. Antioxidant, drug release and in vitro cytotoxicity tests were performed to evaluate the suitability of nanofibers that would be used for wound healing. In vivo wound healing studies on excision and incision wounds created on rat model showed significant reduction of wound area when compared to untreated. The better healing efficiency can be attributed to the presence of curcumin and chitosan.
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| 关 键 词： | 特性评价 静电纺丝 姜黄素 聚乳酸 壳聚糖 纳米薄膜 PLA纤维 伤口愈合 |
Electrospinning of curcumin loaded chitosan/poly （lactic acid） nanofilm and evaluation of its medicinal characteristics |
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| Abstract: | Box-Behnken chitosan curcumin electrospinning poly （lactic acid） （PLA） |
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| Keywords: | Box-Behnken chitosan curcumin electrospinning poly （lactic acid） （PLA） |
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