Milk fat structure of a patient with type 1 hyperlipidemia |
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Authors: | J J Myher A Kuksis G Steiner |
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Affiliation: | (1) Banting and Best Department of Medical Research, University of Toronto, M5G 1L6 Toronto, Ontario, Canada;(2) Department of Medicine, University of Toronto, M5G 1L6 Toronto, Ontario |
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Abstract: | Structural analyses were performed on milk fat samples obtained 3–10 days postpartum from a lactating patient with primary
Type 1 hyperlipidemia. The milk triacylglycerols contained 3–7% C10, 14–21% C12, 20–30% C14, 22–26% C16 and 20–30% C18 (largely oleic) acids. Gas liquid chromatographic (GLC) analyses of the X-1,3- and X-1,2-diacylglycerols on polar siloxane
columns showed a markedly non-random association of acyl chains. Stereospecific analyses indicated that the short chain length
fatty acids were confined essentially to the sn-3-position of the triacylglycerol molecule. Furthermore, these acids were
largely absent from the phosphatidylcholines and the endogenous sn-1,2-diacylglycerols of the milk fat. It is concluded that
the short chain fatty acids are incorporated into the milk triacylglycerols during the final stage of biosynthesis via the
phosphatidic acid pathway, and that the overall fatty acid distribution is consistent with the 1-random 2-random 3-random
hypothesis. |
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Keywords: | |
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