玉米须对Wistar大鼠神经行为的毒性作用

研究了玉米须对Wistar大鼠认知、学习、记忆及神经兴奋度等神经行为的毒性作用。选用测试组合自主活动箱,Morris水迷宫和避暗程序自动控制仪对连续77天经口接受不同剂量玉米须的Wistar大鼠进行测试。自主活动试验结果表明:雄性动物5min平均自主活动量明显高于雌性动物,但各性别动物之间无显著性差异。水迷宫试验显示:雌性试验各组平均游泳距离明显低于雌性对照组,雄性高剂量组动物平均游泳速度提高显著性高于雄性其余各组,其他试验参数之间无显著性差异。避暗试验显示:玉米须各剂量组对Wistar大鼠记忆无毒副作用,相反具有一定促进作用,但无剂量效应关系。连续77天饲喂Wistar大鼠玉米须最高剂量达8.0%(相当于雄性大鼠玉米须日摄入量9.354g/kg体重,雌性大鼠为10.308g/kg体重),对大鼠神经行为无毒副作用,相反在一定程度上能促进动物的记忆能力。

Effects on neurobehavior of Wistar rats with corn silk

the toxicity effects of corn silk on neurobehavior of Wistar rats,including learning,memory and nervous excitation was studied Test system including autonomic activities,Morris water maze,and darkness avoiding were chosen to measure the rats fed with different levels of corn silk for 77 days.Autonomic activities test shows that times of autonomic activities for male animals are higher than that of female nimals,however,there were no significantly difference between groups.Morris water maze test shows that the average swimming distance of female test animals are obviously lower than the ocontrol group,the average swimming speed of high does group in male animals significanly higher than the other groups.Darkness avoiding test shows that corn silk has no side effect on the Wistar rats,in some way,it can promote the ability of memory,but it is does independent.It can be concluded that corn silk has no side effect on neurobehavior of Wistar rats with does up to 8.0%,which corresponds to a mean daily corn silk intake of approximately 9.354 and 10.308 g/kg body weight for males and females,respectively,on the contrary,corn silk can promote the ability of memory.