| pH敏感性壳聚糖/聚乙烯醇水凝胶的制备及其性能研究 |
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| 引用本文： | 谢云涛,宋鹏飞,何玉凤,王荣民. pH敏感性壳聚糖/聚乙烯醇水凝胶的制备及其性能研究[J]. 化工新型材料, 2005, 33(12): 51-53 |
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| 作者姓名： | 谢云涛 宋鹏飞 何玉凤 王荣民 |
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| 作者单位： | 西北师范大学,甘肃省高分子材料重点实验室,兰州,730070 |
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| 基金项目： | 国家自然基金(20274034)，西北师范大学青年教师基金(NWNU-QN-04-27) |
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| 摘 要： | 制备了pH敏感性壳聚糖/聚乙烯醇(CS-PVA)水凝胶,研究了该水凝胶在室温下不同pH值介质中的溶胀比。发现在酸性溶液中,凝胶的溶胀比远大于在碱性溶液中的溶胀比,且其在不同pH值溶液中具有可逆溶胀-收缩行为,对药物氟哌酸具有缓释效果。
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| 关 键 词： | pH敏感性 壳聚糖 聚乙烯醇 半互穿聚合物网络 药物释放 |
| 修稿时间： | 2005-07-08 |
Preparation and pH-sensitive beheviour of chitosan-polyvinyl pyrrolidone hydrogels |
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| Xie Yuntao,Song Pengfei,He Yufeng,Wang Rongmin. Preparation and pH-sensitive beheviour of chitosan-polyvinyl pyrrolidone hydrogels[J]. New Chemical Materials, 2005, 33(12): 51-53 |
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| Authors: | Xie Yuntao Song Pengfei He Yufeng Wang Rongmin |
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| Abstract: | pH-sensitive chitosan-polyvinyl alcohol hydrogels were prepared.The swelling ratio of hydrogels in different pH medium was investigated.The results showed that the ratio of hydrogels in acid medium were higher than the ratio of hydrogels in base medium.Furthermore, The hydrogels had good swelling-contracting reversibility in the solution which pH value was alternately changed,and can be used as the drug-release support of norfloxacin. |
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| Keywords: | pH-sensitivity chitosan polyvinyl alcohol semi-interpenetrating network(Semi-IPN) drug release |
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