黄粉虫油对小鼠血脂水平的影响

以小鼠为试验动物,喂饲基础饲料为正常对照,高脂饲料为模型对照,分别研究不同剂量黄粉虫油掺入其饲料中对高脂血症的预防和治疗作用。结果表明:将高脂饲料中的猪油分别以黄粉虫油替换30%、70%、100%或额外增加3%的虫油喂养30 d,能显著预防其血TG和TC水平的升高,且维持在正常水平;给小鼠喂饲高脂饲料30 d造成其高TG、高TC模型后,维持饲料胆固醇水平不变去掉猪油后,添加3%、7%和10%比例的黄粉虫油和在其高脂饲料基础上另外添加3%的黄粉虫油再喂养20 d,均能显著降低其血清TG含量,但不能降低其血清TC含量及改善其HDL-C和LDL-C比例;且发现黄粉虫油与深海鱼油的作用无显著差异。结论:黄粉虫油既能预防小鼠摄入高脂饲料时血液中TG升高,又能对高血脂小鼠血TG有降低作用;但对小鼠高脂饮食只有预防其血TC含量升高的作用,而不能降低其已升高的血TC。

Effect of Tenebrio Molitor Linneeus Oil on Blood Lipid Level of Mice

Varied dose Tenebrio Molitor Linneeus oil was mixed into the feed of mice to explore the functions of preventing or treating hyperlipidemia,compared with normal control which fed on normal feed and model control which fed on high fat feed.The results showed that Tenebrio Molitor Linneeus oil could evidently prevent hyperlipidemia when mice were fed 30 d,which substituted for 30%,70% and 100% pig oil in high fat feed or be added extra 3%,and could maintain blood lipid of mice on normal level.When mice were fed 20 d continuously again on feed in which cholesterol content was maintain the same as former high fat feed in the mean time pig oil was removed and 3%,7% and 10% Tenebrio Molitor Linneeus oil was mixed.After mice were turned into hyperlipidemia through fed on high fat feed 30d,serum TG level of mice was apparently dropped but serum TC level and the ratio of HDL-C and LDL-C were not varied obviously.And the function of Tenebrio Molitor Linneeus oil was the same as deep sea fish oil.Conclusion:Tenebrio Molitor Linneeus oil can prevent high blood TG level of mice as well as prevent blood TC level of mice fed on high fat feed increasing,but cannot decrease the blood TC level of hyperlipidemia mice.