Enhanced production of rat interleukin-8 by in vitro and in vivo infections with influenza A NWS virus |
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| Authors: | H Ochiai A Ikesue M Kurokawa K Nakajima H Nakagawa |
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| Affiliation: | Department of Virology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan. |
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| Abstract: | We investigated the interleukin-8 (IL-8)-producing activity of influenza A NWS virus in cultured rat kidney NRK-52E cells and a rat influenza model. The production of rat IL-8 increased significantly in the virus-infected cells but not in UV-inactivated virus- or split-product-treated cells. The increase in IL-8 production could be detected in the bronchoalveolar lavage of infected rats. These data suggest that infectious virus has the potential to accelerate the production of IL-8 in cultured cells and in vivo in airway-lining cells. |
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