High Performance,Multiplexed Lung Cancer Biomarker Detection on a Plasmonic Gold Chip |
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| Authors: | Bin Liu Yaling Li Hao Wan Lin Wang Wei Xu Shoujun Zhu Yongye Liang Bo Zhang Jiatao Lou Hongjie Dai Kun Qian |
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| Affiliation: | 1. School of Biomedical Engineering, Shanghai Chest Hospital and Med‐X Research Institute, Shanghai Jiao Tong University, Shanghai, China;2. Department of Chemistry, Stanford University, Stanford, CA, USA;3. Department of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, China;4. Research Center for Advanced Materials and Biotechnology, Research Institute of Tsinghua University in Shenzhen, Shenzhen, China |
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| Abstract: | Diagnosis of lung cancer is performed using a plasmonic gold (pGOLD) chip through multiplexed near‐infrared (NIR) detection of carcino‐embryonic antigen (CEA), Cyfra21‐1, and neuron‐specific enolase (NSE) in the serum samples of patients. With ≈50‐fold enhancement of NIR fluorescence, multiplexed microarray analysis of CEA, Cyfra21‐1, and NSE in 10 μL of human serum or whole blood samples on pGOLD chip leads to markedly improved limit‐of‐quantification, limit‐of‐detection, reproducibility, and higher diagnostic sensitivity and specificity compared to traditional biochips and Luminex technology currently in use in hospitals. |
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| Keywords: | diagnostics lung cancer microarrays plasmonic gold chips serum biomarkers |
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