Tumor‐Responsive Small Molecule Self‐Assembled Nanosystem for Simultaneous Fluorescence Imaging and Chemotherapy of Lung Cancer |
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| Authors: | Yuming Yang Caixia Yue Yu Han Wei Zhang Aina He Chunlei Zhang Ting Yin Qian Zhang Jingjing Zhang Yao Yang Jian Ni Jielin Sun Daxiang Cui |
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| Affiliation: | 1. Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science & Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, P. R. China;2. Department of Orthopedics, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, P. R. China;3. Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, P. R. China;4. National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, Shanghai, P. R. China |
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| Abstract: | Cancer therapeutic drugs face various transportation barriers in transit to the tumor site, making the delivery of effective drug concentrations problematic. Moreover, these drugs are very difficult to use due to their adverse off‐target effects. Thus, it is very essential to develop a drug delivery system that can deliver drugs to achieve effective local concentrations without side effects on healthy tissues. Herein, the authors report a self‐assembled nanodrug system in which hydrophobic antitumor drugs are packaged into nanoparticles to improve water solubility, tumor targeting ability, blood retention time, and chemotherapeutic effect. The nanodrugs are degraded into smaller ones when exposed to the tumor microenvironment, extravasated from leaky regions of the tumor vasculature, and displayed matrix metalloproteinase‐2 (MMP‐2)‐induced degradation and antitumor property. To construct this unique system, an amphiphilic multifunctional molecule (Pep‐Cy5) is synthesized by attaching a MMP‐2‐cleavable peptide to a hydrophobic near‐infrared dye, Cy5. Two hydrophobic anticancer drugs are conjugated to Pep‐Cy5 through hydrophobic interactions to form the self‐assembled nanodrug system. The MMP‐2‐induced degradation and hydrophobic antitumor drug interchangeability features of this nanosystem enable the hydrophobic antitumor drugs to exhibit longer blood‐retention times, improved intratumoral accumulation, fewer side effects, and higher anticancer efficacies compared with free drugs. |
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| Keywords: | chemical therapy matrix metalloproteinase‐2 nanodrug delivery system self‐assemble tumor imaging |
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