| ~(60)Coγ射线体外照射对大鼠脾淋巴细胞在体内原发移行和归巢的影响 |
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| 引用本文： | 杨惠斌,茅子均,殷志伟. ~(60)Coγ射线体外照射对大鼠脾淋巴细胞在体内原发移行和归巢的影响[J]. 辐射防护, 1989, 0(5) |
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| 作者姓名： | 杨惠斌 茅子均 殷志伟 |
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| 作者单位： | 苏州医学院 |
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| 摘 要： | 本文介绍用~(51)Cr 标记淋巴细胞方法,观察了不同剂量~(60)Coγ射线体外照射对大鼠脾淋巴细胞在体内原发移行和归巢的影响。观察结果表明,在注射淋巴细胞悬液后2小时,受照淋巴细胞异常地滞留在肝脏和肺,而归巢到肠系膜淋巴结和肠相关淋巴组织的数量显著减少;辐射对淋巴细胞在体内移行和归巢的影响,除直接与细胞质膜系统损伤有关外,还可能与微丝/微管系统的损伤有关。
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| 关 键 词： | ~（60）Coγ射线 大鼠 淋巴细胞 原发移行 归巢 |
EFFECT OF ~(60)Co-GAMMA RAYS ON THE SPLENIC LYMPHOCYTE PRIMARY MIGRATION IN RATS |
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| Yang Huibin,Mao Zijun,Yin Zhiwei. EFFECT OF ~(60)Co-GAMMA RAYS ON THE SPLENIC LYMPHOCYTE PRIMARY MIGRATION IN RATS[J]. Radiation Protection, 1989, 0(5) |
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| Authors: | Yang Huibin Mao Zijun Yin Zhiwei |
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| Affiliation: | Suzhou Medical College |
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| Abstract: | The effect of various doses of ~(60)Co-gamma rays on the ratsplenic lymphocyte primary migration in vivc was abserved,using a techniqueof gamma counting of ~(51)Cr-labelled lymphocytes.Lymphocytes were treatedwith cytochalasin B or colchicine,and the effect of simple irradiation wascompared with that of irradiation plus either cytoohalasin B or colchicinein order to look into its possible mechanism.The results showed that(1)the irradiated lymphocytes accumulated in abnormal proportions in theliver and lungs and mesenteric lymph nodes and gut-associated lymphoidtissues demonstrated a significant decrease 2 hours after intravenousinjection and that(2)the mechanism of the effect of ionizing radiationon the lymphocyte traffic and homing in vivo may be related to thedestruction of microfilaments and microtubules besides a direct effect onthe lymphocyte plasma membrane. |
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| Keywords: | ~(60)Co-Gamma Rays Rat Lymphocyte Primary Migration Homing |
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