Martefragin A, a novel indole alkaloid isolated from red alga, inhibits lipid peroxidation |
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Authors: | S Takahashi T Matsunaga C Hasegawa H Saito D Fujita F Kiuchi Y Tsuda |
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Affiliation: | Toyama Prefectural Institute for Pharmaceutical Research, Japan. |
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Abstract: | Martefragin A (1), a novel indole alkaloid, was isolated from a red alga, Martensia fragilis, by repeated column chromatography. The structure of 1 was elucidated on the basis of spectral analysis of its methyl ester (2), including 1H- and 13C-NMR, 1H-1H correlation spectroscopy (COSY), and 13C-1H COSY. A single crystal X-ray analysis of the hydrochloride of 1 confirmed the assignment. Martefragin A (1) showed inhibitory activity on NADPH-dependent lipid peroxidation in rat liver microsomes. The IC50 values of 1, alpha-tocopherol and ascorbic acid were 2.8, 87 and 200 microM, respectively. |
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