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A novel apparatus applying long term intermittent cyclic hydrostatic pressure to in vitro cell cultures |
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| Authors: | Myers Kenneth A Shrive Nigel G Hart David A |
| Affiliation: | McCaig Centre for Joint Injury and Arthritis Research, Faculty of Medicine, University of Calgary, NW, Calgary, AB, T2N 4N1, Canada. |
| Abstract: | A novel apparatus has been designed that allows for application of long term intermittent cyclic hydrostatic pressure to in vitro cell cultures, while maintaining cell viability on par with a standard incubator. The system has been tested with monolayer cultures, but could also accommodate three dimensional constructs. |
| Keywords: | hydrostatic pressure bioreactor in vitro cell culture drug delivery mechanobiology mechanotransduction |
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