姜黄素对大鼠角膜碱烧伤的作用

目的:探讨不同浓度姜黄素在大鼠角膜碱烧伤中的作用。方法:建立SD大鼠角膜碱烧伤模型,大鼠分为4组(第1至4组),对照组(第1组)只给予羧甲基纤维素钠,第2,3,4组分别给予100mg/kg BW2、00mg/kg BW及400mg/kg BW姜黄素。在碱烧伤后第3,7,14d用硫代巴比土酸(TBA)法测丙二醛(MDA)含量,化学比色法检测角膜超氧化物歧化酶(SOD)活力。结果:第1,2组之间和第3,4组之间的SOD,MDA无统计学意义。第1,2组与第3,4组相比,后者SOD活力明显增加,MDA含量显著减少。结论:姜黄素对大鼠角膜碱烧伤具有保护作用且与姜黄素浓度有关。

Effects of curcumin on corneal alkali burn in rats

Objective:To explore the effects of different concentrations of curcumin on corneal alkali burn in rats.Methods:The models of corneal alkali burns were induced in S-D rats,all rats were divided into four groups(group 1-4). The control(group 1) rats received only vehicle,those in groups 2,3,and 4 received 100mg/kg BW and 200mg/kg BW curcumin and 400mg/kg BW curcumin,respectively.The content of corneal malondialdehyde(MDA)was determined by thiobarbituric acid test(TBA),the activity of corneal superoxide dismutase(SOD) was determined by chemical colorimetry test at day 3,7,14 after akali bum.Results:There were no statistical significance in group l compared with the group 2 and between group 3 and group 4.compared with group l and 2,activity of SOD in group 3 and 4 increased obviously,and the contents of MDA decreased markedly.Conclusions:Curcumin has protective effects on alkali burned cornea,the effects depend on it's concentrations.